Keywords
epithelization
soft tissue remodeling
oral mucosa
How to Cite
Abstract
Based on the analysis of modern literature, a systematization of information of the soft tissues of the oral cavity remodeling mechanisms after surgical interventions was carried out. Priority area in modern medical practice is the development and use of such methods and drugs that combine maximum safety and high biological activity in relation to body tissues.
A number of scientists have proposed and introduced into practical medicine the technology of programmed scar remodeling. According to this technique, injections of antihomotoxic substances directly around the surgical wound are required, which reduce the duration of edema in the tissues.
A number of authors have studied the use of a minimally invasive microsurgical method based on fractional laser photothermolysis to initiate the regeneration of gums and oral mucosa. As a result of the study, it was found that microscopic thermal wounds in the form of damage islands surrounded by normal viable tissue contribute to stimulation of regeneration, which leads to complete restoration of the tissue without scar formation.
Recently, methods of using directed tissue regeneration have been widely introduced into practice.
In this technique, cellular structures are used that increase the activity of regenerative processes - fibroblasts, platelet plasma.
Great importance in the processes of regeneration of the oral mucosa has the epidermal growth factor EGF. It is a globular protein, acts like a strong mitogen on cells of endodermal, ectodermal and mesodermal origin. The epidermal factor stimulates cell proliferation and, in combination with other cytokines, is a factor that accelerates wound healing and angiogenesis.
For the treatment of patients with periodontal tissue damage, a number of scientists have proposed a method for using an adhesive protective wound cover created with biotechnological high molecular weight hyaluronic acid.
Thus, the analysis of literary sources and the systematization of the available information proves the relevance of further studying the features of the mechanisms of remodeling of soft tissues of the oral cavity. Needs of modern maxillofacial surgery requires morphological study for improvement of existing and development of new treatments for patients.
References
Osobennosti epitelizatsii ranevykh poverkhnostey posle razlichnykh vestibuloplasticheskikh operatsiy pri primenenii khitozana / I.A. Arsenova [i dr.]. // Sibirskiy meditsinskiy zhurnal. – 2010. – No. 2. – P. 132–135. [In Russian].
Kharʹkov L. V. Suchasni pohlyady na mekhanizmy rozvytku patolohichnykh rubtsiv (ohlyad literatury) / L. V. Kharʹkov, YU. O. Mochalov // Novyny stomatolohiyi. – 2010. – No. 1. – P. 9–14. [In Ukrainian].
Miron R. J. Enamel matrix derivative, inflammation and soft tissue wound healing. / R. J. Miron, M. Dard, M. Weinreb // J. Periodontal Res. – 2015. – 50 (5). – Р. 555–569.
Plastychna ta rekonstruktyvna khirurhiya / D. S. Avetikov [ta in.]; za red. D.S. Avetikova. – Poltava, 2013. – 135 p. [In Ukrainian].
T-lymphocytes attenuate dermal scarring by regulating inflammation, neovascularization, and extracellular matrix remodeling / X. Wang [et al.]. // Adv. Wound. Care (New Rochelle). – 2019. – 8 (11). – Р. 527–537.
Bardova K. O. Deyaki aspekty likuvannya rubtsiv / K. O. Bardova // Dermatolohiya ta venerolohiya. – 2015. – No. 1 (67). – P. 55–62. [In Ukrainian].
Korkunda S. V. Prohramovane remodelyuvannya rubtsiv u rekonstruktyvno-plastychniy khirurhiyi / S. V. Korkunda, H. A. Oliynyk // Dermatolohiya ta venerolohiya. – 2017. – 1 (75). – P. 46–52. [In Ukrainian].
Direct and Indirect Roles of Macrophages in Hypertrophic Scar Formation / Y. Feng [et al.]. // Front Physiol. – 2019. – No. 10. – Р. 1101.
Peri-implant bone defects: A 1-year follow-up comparative study of use of hyaluronic acid and xenografts / O. A. Kaya, M. Muglali, D. Torul, I. Kaya // Niger. J. Clin. Pract. – 2019. – 22 (10). – Р. 1388–1395.
Hyaluronic acid as adjunctive to non-surgical and surgical periodontal therapy: a systematic review and meta-analysis / M. Eliezer [et al.]. // Clin Oral Investig. – 2019. – 23 (9). – Р. 3423–3435.
Gistologicheskiy otvet slizistoy obolochki na fraktsionnyy lazernyy fototermoliz / N. D. Gladkova, F. I. Fel'dshteyn, M. M. Karabut i dr. // STM. – 2012. – No. 3. – P. 7–11. [In Russian].
Therapeutic effect of exogenous ghrelin in the healing of gingival ulcers is mediated by the release of endogenous growth hormone and insulin-like growth factor-1 / J. Cieszkowski [et al.]. // J. Physiol Pharmacol. – 2017. – 68 (4). – Р. 609–617.
Nemedikamentoznyye metody lecheniya erozivno-yazvennykh porazheniy polosti rta (obzornaya stat'ya) / YU. A. Makedonova, I. V. Firsova, O. YU. Afanas'yeva, YU. M. Fedotova // Volgogradskiy nauchno-meditsinskiy zhurnal. – 2016. – No. 1. – P. 8–10. [In Russian].
Promoting tissue regeneration by modulating the immune system / Z. Julier, A. J. Park, P. S. Briquez, M. M. Martino // Acta Biomater. – 2017. – No. 53. – Р. 13–28.
Histological evaluation of the effects of growth factors in a fibrin network on bone regeneration / S. Cakir [et al.]. // J. CraniofaP. Surg. – 2019. – 30 (4). – Р. 1078–1084.
Platelet-rich plasma combined with demineralized freeze-dried bone allografts for periodontal regeneration in the treatment of periodontal defects: a meta-analysis / T. Hu [et al.]. // Shanghai Kou Qiang Yi Xue. – 2018. – 27 (5). – Р. 546–553.
Limitations and options using resorbable versus nonresorbable membranes for successful guided bone regeneration / N. K. Soldatos [et al.]. // Quintessence Int. – 2017. – 48 (2). – Р. 131–134.
Sclafani A. P. Platelet-rich fibrin matrix for facial plastic surgery / A. P. Sclafani, M. Saman // Facial. Plast. Surg. Clin. North. Am. – 2012. – No. 20 (2). – Р. 177–186.
Sclafani A. P. Stem cells and molecular advances in the treatment of facial skin / A. P. Sclafani // Facial. Plast. Surg. Clin. North. Am. – 2013. – 21 (1). – Р. 77–80.
Histological evaluation of the effects of growth factors in a fibrin network on bone regeneration / S. Cakir [et al.]. // J. Craniofac Surg. – 2019. – 30 (4). – Р. 1078–1084.
A comprehensive review of advanced biopolymeric wound healing systems / N. Mayet [et al.]. // J. Pharm. Sci. – 2014. – 103 (8). – Р. 2211–2230.
Pop M. A. Biomaterials: A potential pathway to healing chronic wounds? / M. A. Pop, B. D. Almquist // Exp. Dermatol. – 2017. – 26 (9). – Р. 760–763.
Construction of vascularized oral mucosa equivalents using a layer-by-layer cell coating technology / K. Nishiyama, T. Akagi, S. Iwai, M. Akashi // Tissue Eng. Part C: Methods. – 2019. – 25 (5). – Р. 262–275.
Clinical outcomes after the use of complete autologous oral mucosa equivalents: preliminary cases / I. Pena [et al.]. // Oral Surg Oral Med Oral Pathol Oral Radiol. – 2012. – 113 (5). – Р. 4–11.
An infrequent clinical case of mucosal fenestration: Treated with an interdisciplinary approach and regenerative therapy / Z. Jafri, N. Sultan, N. Ahmad, A. Daing // J. Indian. Soc. Periodontol. – 2019. – 23 (2). – Р. 168–171.
Vliyaniye faktorov rosta na regeneratsiyu slizistoy obolochki polosti rta v usloviyakh eksperimental'nogo diabeta / M. M. Zvigintseva [i dr.]. // Sibirskiy meditsinskiy zhurnal. – 2007 – No. 1. – P. 52–55. [In Russian].
In vivo evaluation of an electrospun gelatin nonwoven mat for regeneration of epithelial tissues / S. Strassburg [et al.]. // J. Biomed. Mater. Res. A. – 2019. – 107 (8). – Р. 1605–1614.
Osobennosti regeneratsii slizistoy obolochki polosti rta pri plastike svobodnym desnevym transplantatom / Ye. A. Durnovo [i dr.]. // Meditsinskiy al'manakh. – 2011. – 4 (17). – P. 173–176. [In Russian].
Kolomiyetsʹ S. V. Kontrolʹ perebihu ranovoho protsesu pry operatyvnykh vtruchannyakh u dilyantsi mukohinhivalʹnoho zʺyednannya i fiksovanykh yasen / S. V. Kolomiyetsʹ // Ukrayinsʹkyy stomatolohichnyy alʹmanakh. – 2014. – No. 3. – С. 28–31. [In Ukrainian].
Bhattacharya D. Development of nanotechnology for advancement and application in wound healing: a review / D. Bhattacharya, B. Ghosh, M. Mukhopadhyay // IET Nanobiotechnol. – 2019. – 13 (8). – Р. 778–785.